NREL and Crysalis Biosciences Collaborate to Scale up Domestic Biomanufacturing Technologies

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The left clear sample is the world’s first 100% bio-based acetonitrile that meets oligonucleotide-grade specifications. On the right is aviation fuel blendstock. Photo by Gregory Cooper, NREL
The left clear sample is the world’s first 100% biobased acetonitrile that meets oligonucleotide-grade specifications. On the right is aviation fuel blendstock (photo by Gregory Cooper, NREL).

July 8, 2025 | Originally published by National Renewable Energy Laboratory (NREL) on May 29, 2025

The U.S. Department of Energy’s (DOE’s) National Renewable Energy Laboratory (NREL) is known for its groundbreaking research in impactful bioenergy technologies and invention of performance-advantaged chemicals and materials. But some of its most exciting success stories happen when those innovations move beyond the lab and into the real world.

A prime example of this technology transfer in action is the collaboration between NREL and Crysalis Biosciences, a leading American manufacturer of next-generation biofuels and biochemicals. Based on research initially funded by DOE’s Bioenergy Technologies Office, NREL granted Crysalis commercial licenses to three novel biological technologies to produce biobased chemicals and fuels.

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